Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzene, 1-isocyanato-2-methoxy- → 6-Arylpyrido[2,3-d]pyrimidine deriv. 67
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzene, 1-isocyanato-2-methoxy- | HCID 69695 | — |
| 반응물 | 6-(2,6-dichlorophenyl)-2-N-[3-(4-methylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidine-2,7-diamine | HCID 5328148 | — |
| 용매 | Acetonitrile methanol | HCID 21959252 | — |
| 생성물 | 6-Arylpyrido[2,3-d]pyrimidine deriv. 67 | HCID 5328169 | 69.2% |
반응 단계
6-(2,6-Dichlorophenyl)-N2 -[3-(4-methyl-piperazin-1-yl)-propyl]-pyrido[2,3-d]pyrimidine-2,7-diamine (1.0 g) from Example 36 was reacted with 0.334 g of 2-methoxyphenyl isocyanate according to the general procedure of Example 37 to give 0.9232 g of 1-{6-(2,6-dichlorophenyl)-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-pyrido[2,3-d]pyrimidin-7-yl}-3-(2-methoxy-phenyl)-urea, ESMS (20/80 MeOH/CH3CN+0.1% AcOH): M+ +H=595; mp 152.5°-154° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05733913 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-3f0ff9f57d10448aaa6472d0ca16d530 |
| 출처 메모 | uspto-grants-1998_03 |