Potassium Carbonate → HCID 57217469, 화합물

HRID 343289노트

반응식

HRID 343289 반응식
Cl.[C:2]([NH2:5])(=[NH:4])[CH3:3].C(=O)([O-])[O-].[K+].[K+].Cl[CH:13]([C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1)[C:14](Cl)=[O:15]>O1CCCC1>[CH3:24][O:23][C:20]1[CH:21]=[CH:22][C:17]([C:13]2[C:14](=[O:15])[N:5]=[C:2]([CH3:3])[N:4]=2)=[CH:18][CH:19]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 67170Acetamidine monohydrochlorideHCID 15166130HCID 15166130, 화합물

생성물 1

HCID 57217469HCID 57217469, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
15 °C

실험 절차

A stirred mixture of 11.8 grams (0.10 mole) of acetamidine hydrochloride in 200 mL of tetrahydrofuran is cooled to about 15° C., and 41.8 grams (0.30 mole) of potassium carbonate is added portionwise. To this is then added portionwise 21.8 grams (0.10 mole) of 2-chloro-2-(4-methoxyphenyl)acetyl chloride. Upon completion of addition, the reaction mixture is stirred for 15 minutes at 15° C., then it is warmed to reflux where it stirred for about four hours. The reaction mixture is then cooled and filtered to collect the by-product potassium chloride. The filtrate is concentrated under reduced pressure, yielding 4-(4-methoxyphenyl)-2-methylimidazol-5-one.

후처리

  1. additionUpon completion of addition
  2. temperatureit is warmed
  3. temperatureto reflux where it
  4. stirringstirred for about four hours
  5. temperatureThe reaction mixture is then cooled
  6. filtrationfiltered
  7. customto collect the by-product potassium chloride
  8. concentrationThe filtrate is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-8d72585a46ed49ce8453f38a41e59c15
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05861359

반응 노트

불러오는 중…