5-Amino-2,4-dichloropyrimidine → 2-Chloro-4-methoxypyrimidin-5-amine

HRID 343378노트

반응식

HRID 343378 반응식
[NH2:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[CH3:10][O-:11].[Na+]>CO>[NH2:1][C:2]1[C:3]([O:11][CH3:10])=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 2577975-Amino-2,4-dichloropyrimidineHCID 10942334Sodium Methoxide

생성물 1

HCID 211863562-Chloro-4-methoxypyrimidin-5-amine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 5-amino-2,4-dichloropyrimidine (0.32 g) (obtained as described in Chem. Pharm. Bull., (JAPAN), 1958, 6, 343-346) and a solution of sodium methoxide in methanol (from sodium (0.05 g) and methanol (25 ml)) was heated at reflux for 15 minutes and allowed to cool. Volatile material was removed by evaporation and a small volume of water added. The mixture was extracted twice with ether and the combined extracts were dried (MgSO4) and evaporated to give 5-amino-2-chloro-4-methoxypyrimidine (0.2 g) as an oil; 1H NMR (d6 -DMSO): 3.92 (s, 3H), 5.25 (s, 2H), 7.72 (s, 1H); mass spectrum (+ve CI): 160 (M+H)+.

후처리

  1. temperatureat reflux for 15 minutes
  2. temperatureto cool
  3. customVolatile material was removed by evaporation
  4. additiona small volume of water added
  5. extractionThe mixture was extracted twice with ether
  6. dry with materialthe combined extracts were dried (MgSO4)
  7. customevaporated

출처 및 근거

ORD 기록
ord-87eadb723e31421dbfbe52a42668149d
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05861401

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