Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl isocyanate → 1-[6-(2,6-Dichlorophenyl)-2-{[3-(4-methylpiperazin-1-yl)propyl]amino}pyrido[2,3-d]pyrimidin-7-yl]-3-ethylurea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl isocyanate | HCID 8022 | — |
| 반응물 | 6-(2,6-dichlorophenyl)-2-N-[3-(4-methylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidine-2,7-diamine | HCID 5328148 | — |
| 용매 | Acetonitrile methanol | HCID 21959252 | — |
| 생성물 | 1-[6-(2,6-Dichlorophenyl)-2-{[3-(4-methylpiperazin-1-yl)propyl]amino}pyrido[2,3-d]pyrimidin-7-yl]-3-ethylurea | HCID 5328153 | 74.3% |
반응 단계
6-(2,6-Dichlorophenyl)-N2 -[3-(4-methyl-piperazin-1-yl)-propyl]-pyrido[2,3-d]pyrimidine-2,7-diamine (1.0 g) from Example 36 was reacted with 0.159 g of ethyl isocyanate according to the general procedure of Example 37 to give 0.86 g of 1-{6-(2,6-dichlorophenyl)-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-pyrido-[2,3-d]pyrimidin-7-yl}-3-ethyl-urea, MS (ES+20/80 MeOH/CH3CN+0.1% AcOH): M+ +H=517; mp 82°-90° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05733913 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-779eaaeec17943afacf419b93f07f9f2 |
| 출처 메모 | uspto-grants-1998_03 |