Triethylamine → 3-(Indan-5-yl)-1-methyl-2-thioxo-imidazolidin-4-one

참여 물질

역할	이름	HCID	투입량
반응물	Triethylamine	HCID 8471	—
반응물	Ethyl N-methylaminoacetate hydrochloride	HCID 171173	—
반응물	5-isothiocyanato-2,3-dihydro-1H-indene	HCID 2759357	—
용매	Chloroform	HCID 6212	—
생성물	3-(Indan-5-yl)-1-methyl-2-thioxo-imidazolidin-4-one	HCID 11195962	73.5%

반응 단계

A mixture of sarcosine ethyl ester hydrochloride (6.7 g), indan-5-yl-isothiocyanate (7.7 g), triethyl amine (12 g) and chloroform (300 mL) was heated at reflux for 5 hours. The mixture was cooled to ambient temperature, washed with 1N HCl (2×200 mL) then with water (200 mL) The organic phase was evaporated to dryness. The residue was crystallized from ethyl acetate to give the title compound (7.9 g) as a tan solid, m.p. 158°-160° C. Anal. Calcd. for C13H14N2OS: C, 63.39; H, 5.73; N, 11.37. Found: C, 63.30; H, 5.81; N, 11.31. Mass spectrum (EI, M.+) m/z 246.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US05861517
출처 데이터셋	uspto-grants-1999_01
ORD ID	ord-03b3ef41938641d5ae8165737657860c
출처 메모	uspto-grants-1999_01