Oxalyl chloride → 2-(3,4,5-trimethoxyphenyl)acetyl Chloride
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:13][C:14]([OH:16])=O)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].C(Cl)(=O)C([Cl:20])=O>CN(C)C=O.ClCCl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:13][C:14]([Cl:20])=[O:16])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]참가 물질
5
반응 조건
- 온도
- -5 °C
실험 절차
Combine 3,4,5-trimethoxy-phenyl-acetic acid (2.26 g, 10 mmol) and dichloromethane (50 mL). Cool to -5° C. using a ice-salt bath. Add 2 drops of dimethylformamide followed by dropwise addition of oxalyl chloride (1.74 mL, 20 mmol). after 1 hour, warm the reaction mixture to ambient temperature. After 2 hours, evaporate the reaction mixture in vacuo to give the title compound as a liquid.
후처리
- temperaturewarm the reaction mixture to ambient temperature
- waitAfter 2 hours
- customevaporate the reaction mixture in vacuo
출처 및 근거
- ORD 기록
- ord-6016ca57d90b42e6bab08cf26c2c315b
- 출처 데이터셋
- uspto-grants-1999_01
- 특허 번호
- US05861416
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