4-Phenylpiperidine-4-carboxamide monohydrochloride → 3-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-5-oxo-pyrrolidin-3-yl]-propyl-4-phenyl-piperidine-4-carboxylic acid amide

HRID 343706

반응식

HRID 343706 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:29][CH2:30][CH2:31]CS([O-])(=O)=O)[CH2:13][C:12](=[O:14])[N:11]([C:15](=[O:28])[C:16]3[CH:21]=[C:20]([O:22][CH3:23])[C:19]([O:24][CH3:25])=[C:18]([O:26][CH3:27])[CH:17]=3)[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.[C:38]1([C:44]2([C:50]([NH2:52])=[O:51])[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]2)[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:29][CH2:30][CH2:31][N:47]3[CH2:46][CH2:45][C:44]([C:38]4[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=4)([C:50]([NH2:52])=[O:51])[CH2:49][CH2:48]3)[CH2:13][C:12](=[O:14])[N:11]([C:15](=[O:28])[C:16]3[CH:21]=[C:20]([O:22][CH3:23])[C:19]([O:24][CH3:25])=[C:18]([O:26][CH3:27])[CH:17]=3)[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

3

반응물 2

HCID 30171294-Phenylpiperidine-4-carboxamide monohydrochlorideHCID 867509283-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-5-oxo-pyrrolidin-3-yl]-propyl-methanesulfonate

생성물 1

HCID 542584743-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-5-oxo-pyrrolidin-3-yl]-propyl-4-phenyl-piperidine-4-carboxylic acid amide

실험 절차

Prepare according to the method of example 3.3 using 3-[3-(3,4-dichloro-phenyl)-1(3,4,5-trimethoxy-benzoyl)-5-oxo -pyrrolidin-3-yl]-propyl-methanesulfonate (5 mmol) and 4-phenyl-piperidine-4-carboxylic acid amide hydrochloride (7.5 mmol, 1.5 eq.). Chromatograph on silica gel to give the title compound.

후처리

  1. customPrepare

출처 및 근거

ORD 기록
ord-5053c3cb8b7b44a58e8fc2b2f17b49f6
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05861416

연결된 노트

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