Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloro-1-fluoro-2-nitrobenzene → 5-Chloro-2-[3,4-dihydro-1(2H)-quinolinyl]aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloro-1-fluoro-2-nitrobenzene | HCID 67660 | — |
| 반응물 | 1,2,3,4-Tetrahydroquinoline | HCID 69460 | — |
| 반응물 | 9-Flouro-6-(4-methyl-1-piperazinyl)-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine | HCID 13823288 | — |
| 생성물 | 5-Chloro-2-[3,4-dihydro-1(2H)-quinolinyl]aniline | HCID 19624508 | — |
| 생성물 | 10-chloro-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]benzodiazepine | HCID 20129108 | — |
| 생성물 | 1-(4-Chloro-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline | HCID 21297647 | — |
반응 단계
Starting with 1,2,3,4-tetrahydroquinoline and 5-chloro-2-fluoronitrobenzene and following the steps of 1a to 1f of Example 2, one may obtain, in sequence, 1-(4-chloro-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline, 1-(2-amino-4-chlorophenyl)-1,2,3,4-tetrahydroquinoline, N-[2-{1-(5-chlorophenyl)-1,2,3,4-tetrahydroquinoline-1-yl}]-4-methyl-1-piperazine carboxamide, and 10-chloro-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]benzodiazepine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04761412 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-37f9a56e4374462ea8f84b378b5fce66 |
| 출처 메모 | uspto-grants-1988_08 |