참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Cyanide | HCID 9032 | — |
| 반응물 | Ammonium Carbonate | HCID 517111 | — |
| 반응물 | Water ethanol | HCID 19096565 | — |
| 반응물 | 4-Cyano-2-(2-phenylethynyl)benzaldehyde | HCID 54356802 | — |
| 생성물 | 5-[4-Cyano-2-(2-phenylethynyl)phenyl]hydantoin | HCID 70076578 | — |
반응 단계
A stirred mixture of 4-cyano-2-(2-phenylethynyl)benzaldehyde (0.69 g, 3.0 mmol), potassium cyanide (0.39 g, 6.0 mmol) and ammonium carbonate (1.15 g, 12 mmol) in ethanol-water (1:1, 12 ml) was heated to 85° C. for 4 hours following the procedure described in Example 1 (ii). The crude solid obtained after extraction was chromatographed on flash silica eluting with ether to give 5-[4-cyano-2-(2-phenylethynyl)phenyl]hydantoin as a yellow foam.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05863947 |
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| 출처 데이터셋 | uspto-grants-1999_01 |
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| ORD ID | ord-b7fce059eeff4c118f86826b9ab8acd1 |
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| 출처 메모 | uspto-grants-1999_01 |
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