참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Nitric Acid | HCID 944 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 3,5-Dihydroxyphenylglycine | HCID 108001 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Amino-2-(2-nitro-3,5-dihydroxyphenyl)-acetic acid | HCID 54388458 | — |
반응 단계
2-Amino-2-(3,5-dihydroxyphenyl)-acetic acid (183 mg, 1 mmol) was added portionwise to stirred 5.5M nitric acid (2.5 ml, 15 mmol), which has been cooled to -10° C. in an ice/salt bath. The resulting brown solution was diluted with water (2 ml), neutralised with 2M sodium hydroxide, and purified by cationic exchange chromatography (as in Example 14) to give the title compound as a fluffy yellow solid, m.p. >280° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05863947 |
|---|
| 출처 데이터셋 | uspto-grants-1999_01 |
|---|
| ORD ID | ord-d8b3701b5ba949b5bff96f29c7dfe01c |
|---|
| 출처 메모 | uspto-grants-1999_01 |
|---|
