Trifluoroacetic acid → 4'-[(2-(3-Methylbutyl)-5,6-dimethoxy-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylic acid

HRID 344132

반응식

HRID 344132 반응식
[CH3:1][CH:2]([CH3:38])[CH2:3][CH2:4][C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[C:18]([C:23]([O:25]C(C)(C)C)=[O:24])=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:13][CH:12]=2)[C:8]2[CH:30]=[C:31]([O:36][CH3:37])[C:32]([O:34][CH3:35])=[CH:33][C:7]=2[N:6]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][CH:2]([CH3:38])[CH2:3][CH2:4][C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[C:18]([C:23]([OH:25])=[O:24])=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:13][CH:12]=2)[C:8]2[CH:30]=[C:31]([O:36][CH3:37])[C:32]([O:34][CH3:35])=[CH:33][C:7]=2[N:6]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 15069182Tert.butyl 4'-[(2-(3-methylbutyl)-5,6-dimethoxy-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate

생성물 1

HCID 150693604'-[(2-(3-Methylbutyl)-5,6-dimethoxy-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Prepared in analogous manner to Example 9 from tert.butyl 4'-[(2-(3-methylbutyl)-5,6-dimethoxy-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate and trifluoroacetic acid in methylene chloride.

출처 및 근거

ORD 기록
ord-32fedbddc3704edc882f4ca0f7cc5f0e
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05864043

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