Ammonia → (3S)-5-Oxo-1-[(1S)-1-phenylethyl]-3-pyrrolidinecarboxamide

HRID 344230노트

반응식

HRID 344230 반응식
[C:1]1([C@@H:7]([N:9]2[C:13](=[O:14])[CH2:12][C@H:11]([C:15]([O:17]C)=O)[CH2:10]2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH3:19]>CO>[C:1]1([C@@H:7]([N:9]2[C:13](=[O:14])[CH2:12][C@H:11]([C:15]([NH2:19])=[O:17])[CH2:10]2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 13772856HCID 13772856, 화합물

생성물 1

HCID 54306395(3S)-5-Oxo-1-[(1S)-1-phenylethyl]-3-pyrrolidinecarboxamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl (3S)-1-((S)-1-phenylethyl)-5-oxo-3-pyrrolidinecarboxylate (738 g) was dissolved in methanol (3.5 l). The solution was stirred for 8 hr under ice-cooling while blowing in ammonia gas, and concentrated under reduced pressure to give 537 g of (3S)-1-((S)-1-phenylethyl)-5-oxo-3-pyrrolidinecarboxamide.

후처리

  1. temperaturecooling
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7e028c2a0d4441d7915cc072e27e9c74
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05864039

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