Dodecanoyl chloride → 2-phenyl-4-lauroyl-5-phenyl-(3H)-pyrazol-3-one

HRID 34425

반응식

HRID 34425 반응식
[C:1]1([N:7]2[C:11](=[O:12])[CH:10]=[C:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(C(CCCC)C(Cl)=O)C.[C:29](Cl)(=[O:41])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40]>>[C:1]1([N:7]2[C:11](=[O:12])[C:10]([C:29](=[O:41])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])=[C:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 3

HCID 8166Dodecanoyl chlorideHCID 791032-Ethylhexanoyl chlorideHCID 2457361,3-Diphenyl-1H-pyrazol-5-OL

생성물 1

HCID 201298612-phenyl-4-lauroyl-5-phenyl-(3H)-pyrazol-3-one

실험 절차

Followng the procedure of example 18 with the same proportions but replacing 2-phenyl-5-methyl-(3H)-pyrazol-3-one by 2-phenyl-5-phenyl-(3H)-pyrazol-3-one (MW=136.3 g; mp=136° C.) and 2-ethylhexanoyl chloride by lauroyl chloride a solid product is obtained which after recrystallisation in hexane has a melting point of 69° C.

후처리

  1. customis obtained which
  2. customafter recrystallisation in hexane

출처 및 근거

ORD 기록
ord-17bb29af975c41809ad4b7fc4a34ef83
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04761484

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