Phenyl isocyanate → 4-amino-5-chloro-2-methoxy-N-(1-(4-(3-phenylureido)butyl)pyrrolidin-3-ylmethyl)-benzamide

HRID 344337노트

반응식

HRID 344337 반응식
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH2:19])[CH2:11]1)=[O:7])(C)(C)C.[C:20]1([N:26]=[C:27]=[O:28])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[NH2:29][C:30]1[C:38]([Cl:39])=[CH:37][C:33](C(O)=O)=[C:32]([O:40][CH3:41])[CH:31]=1>>[NH2:29][C:30]1[C:38]([Cl:39])=[CH:37][C:33]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:27]([NH:26][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:28])[CH2:11]2)=[O:7])=[C:32]([O:40][CH3:41])[CH:31]=1

참가 물질

4

반응물 3

HCID 7672Phenyl isocyanateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53780052HCID 53780052, 화합물

생성물 1

HCID 537038284-amino-5-chloro-2-methoxy-N-(1-(4-(3-phenylureido)butyl)pyrrolidin-3-ylmethyl)-benzamide

실험 절차

4-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)butylamine (0.92 g) as starting compound was reacted and treated in the same manner as in Example 34 using phenyl isocyanate (0.37 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.68 g) to give 4-amino-5-chloro-2-methoxy-N-(1-(4-(3-phenylureido)butyl)pyrrolidin-3-ylmethyl)-benzamide.

후처리

  1. customwas reacted

출처 및 근거

ORD 기록
ord-8b506cd1bce14d1d93bd6ccf9e0c4a1d
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05864039

반응 노트

불러오는 중…