1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → N-(6-(4-(4-amino-5-chloro-2-methoxybenzoylaminomethyl)-piperidin-1-yl)hexyl)-1-methyl-1 H-indole-3-carboxamide

HRID 344386

반응식

HRID 344386 반응식
[NH2:1][C:2]1[C:24]([Cl:25])=[CH:23][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][NH2:22])[CH2:12][CH2:11]2)=[O:7])=[C:4]([O:26][CH3:27])[CH:3]=1.[CH3:28][N:29]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[C:31]([C:38](O)=[O:39])=[CH:30]1.ON1C2C=CC=CC=2N=N1.C(N=C=NCCCN(C)C)C>CN(C)C=O>[NH2:1][C:2]1[C:24]([Cl:25])=[CH:23][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][NH:22][C:38]([C:31]3[C:32]4[C:37](=[CH:36][CH:35]=[CH:34][CH:33]=4)[N:29]([CH3:28])[CH:30]=3)=[O:39])[CH2:14][CH2:15]2)=[O:7])=[C:4]([O:26][CH3:27])[CH:3]=1

참가 물질

6

반응물 4

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 8540401-Methylindole-3-carboxylic acidHCID 536836374-Amino-N-(1-(6-aminohexyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide

생성물 1

HCID 54404871N-(6-(4-(4-amino-5-chloro-2-methoxybenzoylaminomethyl)-piperidin-1-yl)hexyl)-1-methyl-1 H-indole-3-carboxamide수율 17.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
0 °C

실험 절차

4-Amino-N-(1-(6-aminohexyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide (1.00 g) was dissolved in dimethylformamide (30 ml). 1-Methylindole-3-carboxylic acid (0.48 g) and 1-hydroxybenzotriazole (0.37 g) were added and the mixture was stirred at 0° C. for 15 min. Then, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (0.53 g) was added, and the mixture was stirred at room temperature for 19 hr. The reaction mixture was concentrated under reduced pressure. Aqueous potassium carbonate solution was added to the residue and the mixture was extracted with ethyl acetate. The extract was dried over magnesium sulfate and concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography to give 0.25 g of N-(6-(4-(4-amino-5-chloro-2-methoxybenzoylaminomethyl)-piperidin-1-yl)hexyl)-1-methyl-1 H-indole-3-carboxamide.

후처리

  1. stirringthe mixture was stirred at room temperature for 19 hr
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. additionAqueous potassium carbonate solution was added to the residue
  4. extractionthe mixture was extracted with ethyl acetate
  5. dry with materialThe extract was dried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure
  7. customThe obtained residue was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-b767ab41bab848ebbfe853cbb5655a54
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05864039

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