Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetaldehyde → 4-amino-5-chloro-N-((1-(5-(N-ethyl-N-(4-nitrobenzyl)amino)pentyl)-piperidin-4-yl)methyl)-2-methoxybenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetaldehyde | HCID 177 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | 4-Amino-5-chloro-2-methoxy-N-((1-(5-(4-nitrobenzylamino)pentyl)-piperidin-4-yl)methyl)benzamide | HCID 54448865 | — |
| 생성물 | 4-amino-5-chloro-N-((1-(5-(N-ethyl-N-(4-nitrobenzyl)amino)pentyl)-piperidin-4-yl)methyl)-2-methoxybenzamide | HCID 53895286 | — |
반응 단계
4-Amino-5-chloro-2-methoxy-N-((1-(5-(4-nitrobenzylamino)pentyl)-piperidin-4-yl)methyl)benzamide (1.5 g) as starting compound, acetaldehyde (0.21 ml) and sodium cyanoborohydride (0.24 g) were reacted and treated in the same manner as in Example 136 to give 0.6 g of 4-amino-5-chloro-N-((1-(5-(N-ethyl-N-(4-nitrobenzyl)amino)pentyl)-piperidin-4-yl)methyl)-2-methoxybenzamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05864039 |
| 출처 데이터셋 | uspto-grants-1999_01 |
| ORD ID | ord-887c6b113f214840b087e8b657ec1d0d |
| 출처 메모 | uspto-grants-1999_01 |