8-Quinolinamine, 7-methyl- → 5-(8-Amino-7-methyl-5-quinolylmethyl)-2,4(1H,3H)-pyrimidinedione

HRID 34446

반응식

HRID 34446 반응식
Cl.CN([CH2:5][C:6]1[C:7](=[O:13])[NH:8][C:9](=[O:12])[NH:10][CH:11]=1)C.[NH2:14][C:15]1[C:16]([CH3:25])=[CH:17][CH:18]=[C:19]2[C:24]=1[N:23]=[CH:22][CH:21]=[CH:20]2>C(O)CO>[NH2:14][C:15]1[C:16]([CH3:25])=[CH:17][C:18]([CH2:5][C:6]2[C:7](=[O:13])[NH:8][C:9](=[O:12])[NH:10][CH:11]=2)=[C:19]2[C:24]=1[N:23]=[CH:22][CH:21]=[CH:20]2

참가 물질

4

반응물 2

HCID 2315568-Quinolinamine, 7-methyl-HCID 122674355-[(dimethylamino)methyl]-1H-pyrimidine-2,4-dione;hydrochloride

생성물 1

HCID 201298195-(8-Amino-7-methyl-5-quinolylmethyl)-2,4(1H,3H)-pyrimidinedione수율 78%

시약·촉매·용매 1

HCID 174Ethylene Glycol용매

실험 절차

A mixture of 8.36 g (0.0406 mole) of 5-[(dimethylamino)methyl]uracil hydrochloride (B. Roth, J. Z. Strelitz, and B. S. Rauckman, J. Med. Chem. 23, 379 (1980) and 6.43 g (0.0406 mole) of 8-amino-7-methylquinoline (R. Long and K. Schofield, J. Chem. Soc. 1953, 2350) in 60 ml of ethylene glycol under nitrogen was heated at 135° for 4 hours. The mixture was cooled and the precipitated solid was collected, washed with ethanol and ether and dried. This crude product was purified by suspension in 550 ml of boiling ethanol and collection of the insoluble product. Yield, 8.90 g of the title compound (78%) m.p. 302°-305° (dec.). Anal. Calcd for C21H20N4 : C, 76.89; H, 6.14; N, 17.06. Found: C, 76.82; H, 6.17; N, 17.04.

후처리

  1. temperatureThe mixture was cooled
  2. customthe precipitated solid was collected
  3. washwashed with ethanol and ether
  4. customdried
  5. customThis crude product was purified by suspension in 550 ml of boiling ethanol
  6. customcollection of the insoluble product
  7. customYield

출처 및 근거

ORD 기록
ord-511a7405e34546f59e9f01059d84fb40
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04761475

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