Ethylene Glycol → 2-[(beta-Hydroxyethoxy)methyl]-4-nitrophenol

HRID 344563

반응식

HRID 344563 반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[CH2:4]Cl.[CH2:13]([OH:16])[CH2:14][OH:15]>>[OH:15][CH2:14][CH2:13][O:16][CH2:4][C:3]1[CH:6]=[C:7]([N+:10]([O-:12])=[O:11])[CH:8]=[CH:9][C:2]=1[OH:1]

참가 물질

3

반응물 2

HCID 174Ethylene GlycolHCID 763052-(Chloromethyl)-4-nitrophenol

생성물 1

HCID 197705092-[(beta-Hydroxyethoxy)methyl]-4-nitrophenol

실험 절차

6.5 moles (93.8 g) of 2-hydroxy-5-nitrobenzyl chloride are heated for 4 hours in 150 ml of ethylene glycol on a boiling water bath. The expected product crystallizes after dilution of the reaction mixture with a litre of iced water. After filtering off followed by drying at 40° C. under air vacuum the product obtained is recrystallized from isopropyl acetate. It melts at 132° C.

후처리

  1. customThe expected product crystallizes after dilution of the reaction mixture with a litre of iced water
  2. filtrationAfter filtering off
  3. customby drying at 40° C. under air vacuum the product
  4. customobtained
  5. customis recrystallized from isopropyl acetate

출처 및 근거

ORD 기록
ord-adfbf402b4a5489faab2c47bad63b721
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05053052

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