3,5-Dimethylpyrazole → 3,5-Dimethylpyrazole

HRID 344678노트

반응식

HRID 344678 반응식
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[NH:4][N:3]=1.Br[CH2:9][CH2:10][Cl:11].BrCCBr>O1CCCC1>[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([CH2:9][CH2:10][Cl:11])[N:3]=1.[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[NH:4][N:3]=1

참가 물질

6

반응물 3

HCID 62103,5-DimethylpyrazoleHCID 78391,2-DibromoethaneHCID 78491-Bromo-2-Chloroethane

생성물 2

HCID 62103,5-DimethylpyrazoleHCID 11499791-(2-chloroethyl)-3,5-dimethyl-1H-pyrazole

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

When an equivalent amount of 3,5-dimethylpyrazole is substituted for 1-ethoxycarbonyl-2H-indazolin-3-one and 2-bromochloroethane is substituted for 1,2-dibromoethane in the procedure of Example 19 using tetrahydrofuran as solvent, 2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl chloride is isolated after column chromatography (3,5-dimethylpyrazole, Aldrich, 24%, C).

출처 및 근거

ORD 기록
ord-3a829151118043718252442deb88f81b
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05053411

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