Urea → 6,7,8-Trimethoxyquinazoline-2,4(1H,3H)-dione

HRID 344712노트

반응식

HRID 344712 반응식
[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[CH:9]=[C:5]([C:6]([OH:8])=O)[C:4]=1[NH2:16].[NH2:17][C:18](N)=[O:19]>O>[CH3:15][O:14][C:10]1[CH:9]=[C:5]2[C:4](=[C:3]([O:2][CH3:1])[C:11]=1[O:12][CH3:13])[NH:16][C:18](=[O:19])[NH:17][C:6]2=[O:8]

참가 물질

4

반응물 2

HCID 1176UreaHCID 966023,4,5-Trimethoxyanthranilic acid

생성물 1

HCID 57434216,7,8-Trimethoxyquinazoline-2,4(1H,3H)-dione수율 45.1%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
145 °C

실험 절차

A mixture of 4.94 g (21.7 mmols) of 3,4,5-trimethoxyanthranilic acid and 15.15 g (249.8 mmols) of urea was heated at 145° C for an hour with stirring. After cooling, water was added and the mixture was heated at the boiling point with stirring. The solid was taken out by filtration and dried to afford 2.47 g (yield: 45%) of 6,7,8-trimethoxyquinazoline-2,4-dione.

후처리

  1. temperatureAfter cooling
  2. temperaturethe mixture was heated at the boiling point
  3. stirringwith stirring
  4. filtrationThe solid was taken out by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-a2fb4af130ef44948c9087476214cf59
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05053408

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