Methyl p-toluenesulfonate → 1,1-Dimethyl-3-hydroxypiperidinium p-toluenesulfonate

HRID 344782

반응식

HRID 344782 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][CH:4]([OH:8])[CH2:3]1.[C:9]1([CH3:20])[CH:14]=[CH:13][C:12]([S:15]([O:18]C)(=[O:17])=[O:16])=[CH:11][CH:10]=1>CC(C)=O>[C:9]1([CH3:20])[CH:10]=[CH:11][C:12]([S:15]([O-:18])(=[O:16])=[O:17])=[CH:13][CH:14]=1.[CH3:1][N+:2]1([CH3:9])[CH2:7][CH2:6][CH2:5][CH:4]([OH:8])[CH2:3]1

참가 물질

4

반응물 2

HCID 6645Methyl p-toluenesulfonateHCID 980163-Piperidinol, 1-methyl-

생성물 1

HCID 150522081,1-Dimethyl-3-hydroxypiperidinium p-toluenesulfonate수율 164.1%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

In 20 ml of acetone was dissolved 2.30 g of 1-methyl-3-piperidinol, and 3.72 g of methyl p-toluenesulfonate was added dropwise to the resulting solution. The mixture was stirred at room temperature, heated under reflux, and cooled to precipitate crystals. The crystals were collected by filtration and dried to give 4.94 g of the desired product, m.p. 125°-127° C. (decomp.).

후처리

  1. additionwas added dropwise to the resulting solution
  2. temperatureheated
  3. temperatureunder reflux
  4. temperaturecooled
  5. customto precipitate crystals
  6. filtrationThe crystals were collected by filtration
  7. customdried

출처 및 근거

ORD 기록
ord-250ba9a0ebc94da1951455139c8420cc
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05053402

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