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2,2,2-Trichloroethyl butyrate → 4-(Tetrahydropyran-2-yloxy)phenylethanol

HRID 344795
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HRID 344795 반응식
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([OH:16])[CH3:15])=[CH:10][CH:9]=1.[C:17](OCC(Cl)(Cl)Cl)(=[O:21])[CH2:18][CH2:19][CH3:20]>C(OCC)C>[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([OH:16])[CH3:15])=[CH:10][CH:9]=1.[C:17]([O:16][CH:14]([C:11]1[CH:12]=[CH:13][C:8]([O:7][CH:2]2[CH2:3][CH2:4][CH2:5][CH2:6][O:1]2)=[CH:9][CH:10]=1)[CH3:15])(=[O:21])[CH2:18][CH2:19][CH3:20]
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참가 물질

5

반응물 2

HCID 5271532,2,2-Trichloroethyl butyrateHCID 539473164-(Tetrahydropyran-2-yloxy)phenylethanol

생성물 2

HCID 539473164-(Tetrahydropyran-2-yloxy)phenylethanol수율 92%HCID 541704431-(4-(Tetrahydro-2-pyranyloxy)phenyl)ethyl butyrate수율 91%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

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온도
25 °C

실험 절차

To 120 ml of anhydrous diethyl ether was added 22.2 g (0.1 mole) of 1-(4-(tetrahydro-2-pyranyloxy)phenyl)ethanol, 22.4 g (0.1 mole) of 2,2,2-trichloroethyl butyrate and 25.2 g of Lipase P, and the mixture was reacted with stirring at 25° C. for 90 hours. After the reaction mixture was filtered by suction to remove Lipase P, the filtrate was concentrated, and the concentrate was then purified by silica gel chromatography [ethyl acetate/n-hexane=1/4 by volume] to give 10.2 g of S-form of 1-(4-(tetrahydro-2-pyranyloxy)phenyl)ethanol (yield: 92%) and 13.1 g of R-form of 1-(4-(tetrahydro-2-pyranyloxy)phenyl)ethyl butyrate (yield: 91%).

후처리

  1. customthe mixture was reacted
  2. filtrationAfter the reaction mixture was filtered by suction
  3. customto remove Lipase P
  4. concentrationthe filtrate was concentrated
  5. customthe concentrate was then purified by silica gel chromatography [ethyl acetate/n-hexane=1/4 by volume]

출처 및 근거

ORD 기록
ord-bc472212bb484b7da45df483971251dc
출처 데이터셋
uspto-grants-1991_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05053507

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