Vinyl valerate → 4-(Tetrahydropyran-2-yloxy)phenylethanol

HRID 344796

반응식

HRID 344796 반응식
C([O:6][CH:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH:16]([O:18][CH2:19][CH3:20])[CH3:17])=[CH:11][CH:10]=1)[CH3:8])(=O)CCC.[C:21]([O:27][CH:28]=[CH2:29])(=[O:26])[CH2:22][CH2:23][CH2:24][CH3:25]>>[O:18]1[CH2:19][CH2:20][CH2:21][CH2:17][CH:16]1[O:15][C:12]1[CH:11]=[CH:10][C:9]([CH:7]([OH:6])[CH3:8])=[CH:14][CH:13]=1.[C:21]([O:27][CH2:28][CH3:29])(=[O:26])[CH2:22][CH2:23][CH2:24][CH3:25]

참가 물질

4

반응물 2

HCID 62497Vinyl valerateHCID 544848551-(4-(1-Ethoxyethoxy)phenyl)ethyl butyrate

생성물 2

HCID 10882Ethyl valerate수율 91%HCID 539473164-(Tetrahydropyran-2-yloxy)phenylethanol수율 94%

실험 절차

The procedure of Example 5 (i) was repeated except that vinyl valerate was used instead of 2,2,2-trichloroethyl butyrate to give 10.4 g of S-form of 1-(4-(tetrahydro-2-pyranyloxy)phenyl)ethanol (yield: 94%) and 13.9 g of R-form of 1-(4-tetrahydro-2-pyranyloxy)phenyl)ethyl valerate (yield: 91%).

출처 및 근거

ORD 기록
ord-0c957c8c3ca3414f86d57079df14e812
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05053507

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