Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(Piperazin-2-YL)benzonitrile → HCID 54273646, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(Piperazin-2-YL)benzonitrile | HCID 4625394 | — |
| 반응물 | 8-Chloro-7-fluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid | HCID 14700554 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | HCID 54273646 | HCID 54273646 | 41.9% |
반응 단계
(RS)-8-[3-(4-Cyanophenyl)-1-piperazinyl]-7-fluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic acid was prepared under the conditions of Example 11, but starting with 8-chloro-7-fluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic acid (1.84 g), (RS)-2-(4-cyanophenyl)piperazine (5.61 g) and triethylamine (1.7 cc). (RS)-8-[3-(4-Cyanophenyl)-1-piperazinyl]-7-fluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic acid (1.15 g) is obtained in the form of a yellow solid, decomposing at 332° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05053509 |
| 출처 데이터셋 | uspto-grants-1991_10 |
| ORD ID | ord-075790bf2de641b09d3fc0f822ecd0e2 |
| 출처 메모 | uspto-grants-1991_10 |