4-(Piperazin-2-YL)benzonitrile → HCID 54273646, 화합물

HRID 344864

반응식

HRID 344864 반응식
Cl[C:2]1[C:3]([F:21])=[CH:4][C:5]2[C:6]([CH:20]=1)=[N:7][C:8]1[N:9]([CH3:19])[CH:10]=[C:11]([C:16]([OH:18])=[O:17])[C:12](=[O:15])[C:13]=1[CH:14]=2.[C:22]([C:24]1[CH:29]=[CH:28][C:27]([CH:30]2[CH2:35][NH:34][CH2:33][CH2:32][NH:31]2)=[CH:26][CH:25]=1)#[N:23]>C(N(CC)CC)C>[C:22]([C:24]1[CH:25]=[CH:26][C:27]([CH:30]2[NH:31][CH2:32][CH2:33][N:34]([C:2]3[C:3]([F:21])=[CH:4][C:5]4[C:6]([CH:20]=3)=[N:7][C:8]3[N:9]([CH3:19])[CH:10]=[C:11]([C:16]([OH:18])=[O:17])[C:12](=[O:15])[C:13]=3[CH:14]=4)[CH2:35]2)=[CH:28][CH:29]=1)#[N:23]

참가 물질

4

반응물 2

HCID 46253944-(Piperazin-2-YL)benzonitrileHCID 147005548-Chloro-7-fluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid

생성물 1

HCID 54273646HCID 54273646, 화합물수율 41.9%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

(RS)-8-[3-(4-Cyanophenyl)-1-piperazinyl]-7-fluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic acid was prepared under the conditions of Example 11, but starting with 8-chloro-7-fluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic acid (1.84 g), (RS)-2-(4-cyanophenyl)piperazine (5.61 g) and triethylamine (1.7 cc). (RS)-8-[3-(4-Cyanophenyl)-1-piperazinyl]-7-fluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic acid (1.15 g) is obtained in the form of a yellow solid, decomposing at 332° C.

후처리

  1. custom(RS)-8-[3-(4-Cyanophenyl)-1-piperazinyl]-7-fluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic acid was prepared under the conditions of Example 11

출처 및 근거

ORD 기록
ord-075790bf2de641b09d3fc0f822ecd0e2
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05053509

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