Sodium Carbonate → 1,8-Naphthyridine

HRID 344913

반응식

HRID 344913 반응식
[CH2:1]([O:3][C:4]([C:6]1[C:7](=[O:23])[C:8]2[CH:9]=[C:10]3[CH:20]=[C:19]([F:21])[C:18](F)=[CH:17][C:11]3=[N:12][C:13]=2[N:14]([CH3:16])[CH:15]=1)=[O:5])[CH3:2].[CH2:24]1[O:32][C:31]2[CH:30]=[CH:29][C:28]([CH:33]3[CH2:38][NH:37][CH2:36][CH2:35][NH:34]3)=[CH:27][C:26]=2[O:25]1.C(=O)([O-])[O-].[Na+].[Na+]>>[CH2:1]([O:3][C:4]([C:6]1[C:7](=[O:23])[C:8]2[CH:9]=[C:10]3[CH:20]=[C:19]([F:21])[C:18]([N:37]4[CH2:36][CH2:35][NH:34][CH:33]([C:28]5[CH:29]=[CH:30][C:31]6[O:32][CH2:24][O:25][C:26]=6[CH:27]=5)[CH2:38]4)=[CH:17][C:11]3=[N:12][C:13]=2[N:14]([CH3:16])[CH:15]=1)=[O:5])[CH3:2].[N:12]1[C:13]2[C:8](=[CH:7][CH:6]=[CH:15][N:14]=2)[CH:9]=[CH:10][CH:11]=1

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 27717712-(1,3-Benzodioxol-5-yl)piperazineHCID 98399873-Ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine

생성물 2

HCID 1360691,8-Naphthyridine수율 661.4%HCID 53975414HCID 53975414, 화합물

실험 절차

(RS)-3-Ethoxycarbonyl-7-fluoro-1-methyl-8-[3-(3,4-methylenedioxyphenyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine was prepared under conditions similar to Example 39, but starting with 3-ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (1.59 g), (RS)-2-(3,4-methylenedioxyphenyl)piperazine (1.25 g) and sodium carbonate (0.64 g). (RS)-3-Ethoxycarbonyl-7-fluoro-1-methyl-8-[3-(3,4-methylenedioxyphenyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8 naphthyridine (2.15 g) is obtained in the form of a yellow solid, m.p. 252° C.

출처 및 근거

ORD 기록
ord-1a2672ea7e304abca0f88808b0986ebd
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05053509

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