Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropyl Ether → Benzhydryl 7-[2-(2-tritylaminothiazol-4-yl)-2-difluoromethoxyiminoacetamido]-3-(1-methyl-1-pyrrolidiniomethyl)-3-cephem-4-carboxylate-1-oxide iodide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropyl Ether | HCID 7914 | — |
| 반응물 | 1-Methylpyrrolidine | HCID 8454 | — |
| 반응물 | Benzhydryl 7-[2-(2-tritylaminothiazol-4-yl)-2-difluoromethoxyiminoacetamido]-3-iodomethyl-3-cephem-4-carboxylate-1-oxide | HCID 131715683 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Benzhydryl 7-[2-(2-tritylaminothiazol-4-yl)-2-difluoromethoxyiminoacetamido]-3-(1-methyl-1-pyrrolidiniomethyl)-3-cephem-4-carboxylate-1-oxide iodide | HCID 131715681 | — |
반응 단계
A solution of benzhydryl 7-[2-(2-tritylaminothiazol-4-yl)-2-difluoromethoxyiminoacetamido]-3-iodomethyl-3-cephem-4-carboxylate-1-oxide (syn isomer) (1.97 g) and N-methylpyrrolidine (204 mg) in tetrahydrofuran (10 ml) was stirred for 40 minutes at 0°-5° C. and then diisopropyl ether was added thereto. The resultant precipitates were collected by filtration, washed with diisopropyl ether and air-dried to give benzhydryl 7-[2-(2-tritylaminothiazol-4-yl)-2-difluoromethoxyiminoacetamido]-3-(1-methyl-1-pyrrolidiniomethyl)-3-cephem-4-carboxylate-1-oxide iodide (syn isomer) (2.12 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04761410 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-7fa97aacc8b343b488a1eb5df8f9f917 |
| 출처 메모 | uspto-grants-1988_08 |