2-Amino-4-Nitrophenol → 2-(Chloromethyl)-5-nitro-1,3-benzoxazole

HRID 345028

반응식

HRID 345028 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[OH:11].Cl.[Cl:13][CH2:14][C:15](=N)OCC>C(O)C>[Cl:13][CH2:14][C:15]1[O:11][C:3]2[CH:4]=[CH:5][C:6]([N+:8]([O-:10])=[O:9])=[CH:7][C:2]=2[N:1]=1

참가 물질

4

반응물 2

HCID 36133892-Amino-4-NitrophenolHCID 12470659Ethyl 2-chloroethanecarboximidate hydrochloride

생성물 1

HCID 27641892-(Chloromethyl)-5-nitro-1,3-benzoxazole

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-Amino-4-nitrophenol (10 g, 65 mmole) and ethyl chloroacetimidate hydrochloride (15.4 g, 97.5 mmole) were heated at reflux temperature in ethanol (100 ml) for 18 hours. The solvent was then removed by evaporation in vacuo and the residue recrystallised from ethanol to give the title compound, yield 9.0 g, m.p. 216°-217°.

후처리

  1. customThe solvent was then removed by evaporation in vacuo
  2. customthe residue recrystallised from ethanol

출처 및 근거

ORD 기록
ord-a27496733853466f80a3f59eb0fe0137
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05055473

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