Methanesulfonyl chloride → N-(2-Methylquinolin-6-yl)methanesulfonamide

HRID 345042

반응식

HRID 345042 반응식
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[CH:11]=[CH:10]2>N1C=CC=CC=1>[CH3:1][S:2]([NH:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[CH:11]=[CH:10]2)(=[O:4])=[O:3]

참가 물질

4

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 1031482-Methylquinolin-6-amine

생성물 1

HCID 19813426N-(2-Methylquinolin-6-yl)methanesulfonamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Methanesulphonyl chloride (6.2 ml) was added dropwise to a stirred solution of 6-amino-2-methylquinoline (12.5 g) in pyridine (100 ml) cooled to 5°. Stirring was continued for 17 hours at room temperature. The pyridine was then removed by evaporation in vacuo, the residue diluted with aqueous sodium bicarbonate, and extracted three times with methylene chloride. The combined organic extracts were combined, dried (MgSO4) and evaporated in vacuo to give the title compound, yield 13.0 g, m.p. 151°-153°.

후처리

  1. temperaturecooled to 5°
  2. customThe pyridine was then removed by evaporation in vacuo
  3. additionthe residue diluted with aqueous sodium bicarbonate
  4. extractionextracted three times with methylene chloride
  5. dry with materialdried (MgSO4)
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-791cb89a953e43a6977715154fc64535
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05055473

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