Butoxy(oxo)acetate → Butyl 2-oxo-2-((3-(2H-tetrazol-5-yl)phenyl)amino)acetate

반응식

[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:12][N:11]=[N:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:13]([O:17][C:18](=[O:22])[C:19]([O-])=[O:20])[CH2:14][CH2:15][CH3:16]>>[CH3:16][CH2:15][CH2:14][CH2:13][O:17][C:18]([C:19]([NH:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12]=[N:11][NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1)=[O:20])=[O:22]

참가 물질

반응물 2

HCID 21904025Butoxy(oxo)acetate

HCID 178507542HCID 178507542, 화합물

생성물 1

HCID 5380Butyl 2-oxo-2-((3-(2H-tetrazol-5-yl)phenyl)amino)acetate수율 75%

실험 절차

5-(3-Aminophenyl)tetrazole (1.7 g) was added to 12 ml of n-butyloxalate and reacted at a bath temperature of 165° to 175° C. for 1.5 hr while stirring. After cooling, the precipitated crystals were filtered off and recrystallized from acetone-n-hexane, to give 2.3 g (yield: 75%) of 5-(3-n-butyloxalylaminophenyl)tetrazole.

후처리

customreacted at a bath temperature of 165° to 175° C. for 1.5 hr
temperatureAfter cooling
filtrationthe precipitated crystals were filtered off
customrecrystallized from acetone-n-hexane

출처 및 근거

ORD 기록: ord-7783e3201b35458f99cdad4e8b609dc6
출처 데이터셋: uspto-grants-1991_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05055481

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