Dichloromethane → 3-Isopropyl-4-(2-acetoxyethyl)-azetidinone
반응식
[CH:1]([C@H:4]1[C@H:7]([CH2:8][CH2:9][OH:10])[NH:6][C:5]1=[O:11])([CH3:3])[CH3:2].C(Cl)Cl.[C:15](Cl)(=[O:17])[CH3:16]>N1C=CC=CC=1>[CH:1]([CH:4]1[CH:7]([CH2:8][CH2:9][O:10][C:15](=[O:17])[CH3:16])[NH:6][C:5]1=[O:11])([CH3:3])[CH3:2]참가 물질
5
실험 절차
Trans-3-isopropyl-4-(2-hydroxyethyl)-2-azetidinone from Step B, is dissolved in 10 ml. CH2Cl2 and cooled to 0° C. Pyridine 0.75 ml is added and then 0.392 ml of acetyl chloride is added dropwise. The mixture is stirred at 0° for 15 min and then at 25° C. for another 15 minutes. The reaction mixture is evaporated to dryness. The residue is chromatographed on silica gel using 50% EtOAc/C6H6 as eluant to give 0.652 g 3-isopropyl-4-(2-acetoxyethyl)-azetidinone.
후처리
- waitat 25° C. for another 15 minutes
- customThe reaction mixture is evaporated to dryness
- customThe residue is chromatographed on silica gel using 50% EtOAc/C6H6 as eluant
출처 및 근거
- ORD 기록
- ord-a2c8a14b156d4883bc6ac754fa8616f3
- 출처 데이터셋
- uspto-grants-1991_10
- 특허 번호
- US05055573
반응 노트
불러오는 중…