Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → alpha-Methyl-4-pyridinemethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Ethyl pyridine-4-acetate | HCID 736321 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | alpha-Methyl-4-pyridinemethanol | HCID 90919 | — |
반응 단계
A solution of 23.8 g of ethyl 4-pyridylacetate in 100 ml of anhydrous tetrahydrofuran is added dropwise to 5.5 g of lithium aluminum hydride in 150 ml of anhydrous tetrahydrofuran under nitrogen. The mixture is heated at 50° (bath) for 40 minutes, then cooled in an ice bath, and the excess lithium aluminum hydride is decomposed by addition of 6.6 ml of water followed by 6.6 ml of 15% aqueous sodium hydroxide and 20 ml of water. The solid is filtered off and the filtrate concentrated in vacuo to yield 4-pyridylethanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05057506 |
| 출처 데이터셋 | uspto-grants-1991_10 |
| ORD ID | ord-ad4343eb7d2843ecb9685c7698606106 |
| 출처 메모 | uspto-grants-1991_10 |