Water → alpha-Methyl-4-pyridinemethanol

HRID 345338

반응식

HRID 345338 반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8](OCC)=O)=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH2:19].[OH-].[Na+]>O1CCCC1>[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([OH:19])[CH3:8])=[CH:3][CH:2]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 736321Ethyl pyridine-4-acetateHCID 21226445Aluminium lithium hydride2회

생성물 1

HCID 90919alpha-Methyl-4-pyridinemethanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 23.8 g of ethyl 4-pyridylacetate in 100 ml of anhydrous tetrahydrofuran is added dropwise to 5.5 g of lithium aluminum hydride in 150 ml of anhydrous tetrahydrofuran under nitrogen. The mixture is heated at 50° (bath) for 40 minutes, then cooled in an ice bath, and the excess lithium aluminum hydride is decomposed by addition of 6.6 ml of water followed by 6.6 ml of 15% aqueous sodium hydroxide and 20 ml of water. The solid is filtered off and the filtrate concentrated in vacuo to yield 4-pyridylethanol.

후처리

  1. temperatureThe mixture is heated at 50° (bath) for 40 minutes
  2. temperaturecooled in an ice bath
  3. filtrationThe solid is filtered off
  4. concentrationthe filtrate concentrated in vacuo

출처 및 근거

ORD 기록
ord-ad4343eb7d2843ecb9685c7698606106
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05057506

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