Ethyl 4-(2-hydroxyethyl)picolinate → Ethyl 4-(2-hydroxyethyl)piperidine-2-carboxylate
반응식
[OH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=1>C(O)(=O)C.[Pt]=O>[OH:1][CH2:2][CH2:3][CH:4]1[CH2:9][CH2:8][NH:7][CH:6]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:5]1참가 물질
4
실험 절차
A mixture of 8.37 g of ethyl 4-(2-hydroxyethyl)-pyridine-2-carboxylate in 130 ml acetic acid and 4 g platinum oxide is hydrogenated at 50 lbs/in2. Filtration, concentration in vacuo, neutralization with potassium carbonate and extraction with methylene chloride yields an oil that is purified by flash chromatography using methylene chloride/methanol saturated with ammonia (20:1) to yield ethyl 4-(2-hydroxyethyl)-piperidine-2-carboxylate.
후처리
- filtrationFiltration, concentration in vacuo, neutralization
- extractionwith potassium carbonate and extraction with methylene chloride
- customyields an oil that
- customis purified by flash chromatography
출처 및 근거
- ORD 기록
- ord-71d3cb5cf1974ae6a157575efc5397e0
- 출처 데이터셋
- uspto-grants-1991_10
- 특허 번호
- US05057506
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