Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 5-Fluoro-1-methylcarbamoylisatin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methyl Isocyanate | HCID 12228 | — |
| 반응물 | 5-Fluoroisatin | HCID 236566 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-Fluoro-1-methylcarbamoylisatin | HCID 14229948 | 74.5% |
반응 단계
A mixture of 5-fluoroisatin (9.9 g), triethylamine (1 ml) and dimethylformamide (30 ml) is stirred under ice-cooling, and thereto is added dropwise methyl isocyanate (3 g) at the same temperature. The mixture is stirred at room temperature for 30 minutes, and the precipitates are taken by filtration to give 5-fluoro-1-methylcarbamoylisatin (8.7 g). M.p. 230°-232° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04762839 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-c25576f7a14c4b82ae9916dfb75fb8cd |
| 출처 메모 | uspto-grants-1988_08 |