Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → Ethyl 4-(1H-imidazol-1-yl)benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | Dimethylacetamide | HCID 31374 | — |
| 반응물 | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Ethyl 4-(1H-imidazol-1-yl)benzoate | HCID 13423940 | 33.3% |
반응 단계
A mixture of 13.6 parts of 1H-imidazole, 16.8 parts of ethyl 4-fluorobenzoate, 0.1 parts of potassium iodide and 54 parts of N,N-dimethylacetamide was stirred and refluxed for 20 hours. The reaction mixture was cooled to room temperature and poured onto a lot of water. The product was extracted a few times with benzene. The combined extracts were washed thoroughly with water, dried, filtered and evaporated. The residue was stirred in hexane. The product was filtered off and dried, yielding 7.2 parts (33.3%) of ethyl 4-(1H-imidazol-1-yl)benzoate; mp. 100.3° C. (intermediate 18).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05057525 |
| 출처 데이터셋 | uspto-grants-1991_10 |
| ORD ID | ord-30bea23f83bd45a6a20762b1f619e7ef |
| 출처 메모 | uspto-grants-1991_10 |