3-(1-methyl-3-indolyl)-4-[1-[3-(methylsulphonyloxy)propyl]-3-indolyl]-1H-pyrrole-2,5-dione → HCID 18780280, 화합물

HRID 345679

반응식

HRID 345679 반응식
[SH:1][C:2]1[S:3][CH2:4][CH2:5][N:6]=1.[CH3:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]2[C:18](=[O:40])[NH:19][C:20](=[O:39])[C:21]=2[C:22]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[N:24]([CH2:31][CH2:32][CH2:33]OS(C)(=O)=O)[CH:23]=2)=[CH:9]1>>[CH3:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]2[C:18](=[O:40])[NH:19][C:20](=[O:39])[C:21]=2[C:22]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[N:24]([CH2:31][CH2:32][CH2:33][S:1][C:2]3[S:3][CH2:4][CH2:5][N:6]=3)[CH:23]=2)=[CH:9]1

참가 물질

3

반응물 2

HCID 151630513-(1-methyl-3-indolyl)-4-[1-[3-(methylsulphonyloxy)propyl]-3-indolyl]-1H-pyrrole-2,5-dioneHCID 178527880HCID 178527880, 화합물

생성물 1

HCID 18780280HCID 18780280, 화합물수율 17.2%

실험 절차

In an analogous manner to that described in Example 59, from 27 mg of 2-mercaptothiazoline and 100 mg of the product of Example 58, there were obtained 18 mg of 3-(1-methyl-3-indolyl)-4-[1-[3-(2-thiazolin-2-ylthio)propyl]-3-indolyl]-1H-pyrrole-2,5-dione m.p. 170°-173° C.

출처 및 근거

ORD 기록
ord-03094ac0710b42b29b17f0b6898cda9c
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05057614

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