Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-Amino-2-chloro-5-fluoro-4-methylbenzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Dithionite | HCID 24489 | — |
| 반응물 | 2-Chloro-5-fluoro-4-methyl-3-nitro-benzoic acid | HCID 13657439 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 2-Methoxyethanol | HCID 8019 | — |
| 생성물 | 3-Amino-2-chloro-5-fluoro-4-methylbenzoic acid | HCID 13657440 | — |
반응 단계
18.5 g of 2-chloro-5-fluoro-4-methyl-3-nitro-benzoic acid and 51.5 g of Na2S2O4 are boiled in a mixture of 160 ml of glycol monomethyl ether and 160 g of water for 3 hours. 230 ml of 1/2-concentrated HCl are added to the still warm solution. The mixture is boiled up once more, cooled and poured into 560 ml of water. The solid which has precipitated is isolated and dried. Yield: 12.4 g, melting point: 182°-84°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04762844 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-59d9ecf81f1c4d51bdbef875b42cf00b |
| 출처 메모 | uspto-grants-1988_08 |