Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-Benzyl-3-(2-chloroethylamino)pyrrolidine-2,5-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Benzylmaleimide | HCID 74204 | — |
| 반응물 | 2-Chloroethylamine hydrochloride | HCID 9793737 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-Benzyl-3-(2-chloroethylamino)pyrrolidine-2,5-dione | HCID 15070002 | — |
반응 단계
74.8 g (0.4 mol) of N-benzylmaleimide are reacted with 58 g (0.5 mol) of 2-chloroethylamine hydrochloride and 50.5 g (0.5 mol) of triethylamine in accordance with the working instructions of Example Ia. After working up by chromatography, 81.6 g (77% of theory) of an oil with an RF value of 0.24 (on silica gel using ethyl acetate:petroleum ether=1:1) are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05059597 |
| 출처 데이터셋 | uspto-grants-1991_10 |
| ORD ID | ord-693c3e101c4740969cfe48357afaed28 |
| 출처 메모 | uspto-grants-1991_10 |