3-(2,4,5-Trifluorophenyl)prop-2-yn-1-ol → 3-(2,4,5-Trifluorophenyl)propan-1-ol

HRID 345895노트

반응식

HRID 345895 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[C:10]#[C:11][CH2:12][OH:13]>C(OCC)C.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[CH2:10][CH2:11][CH2:12][OH:13]

참가 물질

4

반응물 1

HCID 199916063-(2,4,5-Trifluorophenyl)prop-2-yn-1-ol

생성물 1

HCID 199916093-(2,4,5-Trifluorophenyl)propan-1-ol

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 3283Diethyl Ether용매

실험 절차

A solution of 3-(2,4,5-trifluorophenyl)prop-2-yn-1-ol (90 mg, 0.48 mmol) in diethyl ether (10 ml) was hydrogenated over 10% palladium on carbon at room temperature for 15 hours. The mixture was filtered through celite and the filtrate on evaporation gave an oil, which was flash chromatographed on silica using 10% ethyl ether/hexane. Fractions with Rf of about 0.16 on evaporation gave the title alcohol as a colorless oil.

후처리

  1. filtrationThe mixture was filtered through celite
  2. customthe filtrate on evaporation
  3. customgave an oil, which
  4. customchromatographed on silica using 10% ethyl ether/hexane
  5. customFractions with Rf of about 0.16 on evaporation

출처 및 근거

ORD 기록
ord-2964f7ce8eaa4b838ec7af6274bf41a1
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05059611

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