Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 1-[2-Amino-6-(2,6-difluorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | tert-Butyl isocyanate | HCID 62412 | — |
| 반응물 | 6-(2,6-Difluoro-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine | HCID 21850057 | — |
| 용매 | Methane | HCID 297 | — |
| 생성물 | 1-[2-Amino-6-(2,6-difluorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea | HCID 5329115 | — |
반응 단계
The title compound was prepared from 0.25 g of 6-(2,6-difluoro-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 63 and 0.112 mL of tert-butyl isocyanate according to Example 2. The product was purified by MPLC eluting with a gradient of CHCl3 :EtOAc (1:1) to EtOAc to afford the pure product; mp >300° C., CIMS (1% ammonia in methane): m/z (relative intensity) 373 (MH+ +1, 60), 374 (MH+ +2, 10), 274 (100).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05733913 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-f181ec7fa91846eca2529e969dd97cf0 |
| 출처 메모 | uspto-grants-1998_03 |