5-Fluoro-4-methyl-2-nitrobenzoic acid → 2-Amino-5-fluoro-4-methylbenzoic acid

HRID 34591노트

반응식

HRID 34591 반응식
[N+:1]([C:4]1[CH:12]=[C:11]([CH3:13])[C:10]([F:14])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-])=O>O1CCOCC1.[Pd]>[NH2:1][C:4]1[CH:12]=[C:11]([CH3:13])[C:10]([F:14])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

참가 물질

4

반응물 1

HCID 136574495-Fluoro-4-methyl-2-nitrobenzoic acid

생성물 1

HCID 136574502-Amino-5-fluoro-4-methylbenzoic acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 312751,4-Dioxane용매

실험 절차

525 g of 2-nitro-4-methyl-5-fluoro-benzoic acid are hydrogenated in 3 l of dioxane with 50 g of 5% strength Pd-C catalyst at 30°-40° under 20-30 bar. The catalyst is filtered off with suction and the solution is poured onto water. The crystals which have precipitated are filtered off with suction and dried. Yield: 357 g (80.1% of theory), melting point: 201°-202° C.

후처리

  1. filtrationThe catalyst is filtered off with suction
  2. additionthe solution is poured onto water
  3. customThe crystals which have precipitated
  4. filtrationare filtered off with suction
  5. customdried

출처 및 근거

ORD 기록
ord-e46f2afba65f4f8c8a73c8e0d2d83634
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04762844

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