Sulfuric Acid → Pyrazolo[1,5-a]pyrimidine-3-carboxamide
반응식
[N:1]1[N:5]2[CH:6]=[CH:7][CH:8]=[N:9][C:4]2=[C:3]([C:10]#[N:11])[CH:2]=1.S(=O)(=O)(O)[OH:13]>>[N:1]1[N:5]2[CH:6]=[CH:7][CH:8]=[N:9][C:4]2=[C:3]([C:10]([NH2:11])=[O:13])[CH:2]=1참가 물질
3
실험 절차
As shown hereinabove a pyrazolo(1,5-a)pyrimidine-3-carbonitrile (4) (prepared in the manner described in U.S. Pat. Nos. 4,281,000; 4,236,005 and 4,178,499) is stirred with concentrated sulfuric acid at room temperature for from 2-20 hours. The mixture is carefully poured onto ice and the precipitate is collected, neutralized with sodium hydroxide, ammonium hydroxide or saturated sodium bicarbonate and the like and washed with water to obtain the corresponding pyrazolo(1,5-a)pyrimidine-3-carboxamide compound (3).
후처리
- customprepared in the manner
- additionThe mixture is carefully poured onto ice
- customthe precipitate is collected
- washthe like and washed with water
출처 및 근거
- ORD 기록
- ord-5f1fad99517f4f82985dfcf0162ae970
- 출처 데이터셋
- uspto-grants-1991_10
- 특허 번호
- US05059691
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