Bromine → 2-Bromo-3,4-dihydro-7-methoxy-1(2H)-naphthalenone

HRID 346049

반응식

HRID 346049 반응식
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9][C:10]2=[O:13])=[CH:5][CH:4]=1.[Br:14]Br>CCOCC>[Br:14][CH:9]1[CH2:8][CH2:7][C:6]2[C:11](=[CH:12][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[C:10]1=[O:13]

참가 물질

4

반응물 2

HCID 24408BromineHCID 812767-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one

생성물 1

HCID 3119062-Bromo-3,4-dihydro-7-methoxy-1(2H)-naphthalenone수율 87.2%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a 10° C. solution of 25 g (0.142 mol) of 7-methoxy-3,4-dihydro-1(2H)-naphthalenone in 1 liter ether was added dropwise (maintaining reaction temperature at about 10° C.) 37.9 g (0.237 mol) of bromine. The reaction solution was concentrated on a rotating evaporator and the residue crystallized from ether to give 31.6 g (87%) of present title compound, m.p. 79°-80° C.

후처리

  1. concentrationThe reaction solution was concentrated on a rotating evaporator
  2. customthe residue crystallized from ether

출처 및 근거

ORD 기록
ord-407b83681b2f42e0a0bdbfab46312e39
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05059609

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