Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Aminophenol → 1-methyl-3-trifluoromethyl-5-(4-aminophenoxy)-1H-1,2,4-triazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Aminophenol | HCID 403 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 1-methyl-3-trifluoromethyl-5-methylsulfonyl-1H-1,2,4-triazole | HCID 21298098 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 1-methyl-3-trifluoromethyl-5-(4-aminophenoxy)-1H-1,2,4-triazole | HCID 21298114 | — |
반응 단계
8 g of pulverised KOH are added to 10.9 g of p-aminophenol in 120 ml of dimethyl sulfoxide, and the mixture is stirred for 1/2 hour. Then 22.9 g of 1-methyl-3-trifluoromethyl-5-methylsulfonyl-1H-1,2,4-triazole are added, the reaction mixture is stirred for a further 2 hours and subsequently poured into 1 liter of ice water. The precipitated product is isolated by filtration, washed with water and dried. Yield: 19.6 g (76% of theory). Melting point: 111°14 112° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04762830 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-b6d4d59afe9d44019b8ad838f81e0291 |
| 출처 메모 | uspto-grants-1988_08 |