Sulfuric Acid → HCID 19990493, 화합물
반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]2[C:15]([N:16]=1)=[CH:14][CH:13]=[CH:12][N:11]=2.S(=O)(=O)(O)O>O.C(O)(=O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]2[C:15]([N:16]=1)=[CH:14][C:13]([C:8](=[O:9])[CH2:3][CH2:2][CH3:7])=[CH:12][N:11]=2참가 물질
5
실험 절차
Using the procedure described in Example 1, but replacing 2-phenyloxazolo[4,5-b]pyridine by 2-(2-fluorophenyl)oxazolo[5,4-b]pyridine (J. Med. Chem. 1978, 21, 11, 1158+) and using 8.4 ml of concentrated sulfuric acid in 16.8 ml of water and 16.8 ml of acetic acid, and after purification on a column of silica (40 to 63μ; 70-230 mesh; eluent: ethyl acetate/toluene, 1:9), the product of the title is obtained.
후처리
- customafter purification on a column of silica (40 to 63μ; 70-230 mesh; eluent: ethyl acetate/toluene, 1:9)
- customthe product of the title is obtained
출처 및 근거
- ORD 기록
- ord-b3f8e3a548fb4fb5bc127e991fc64051
- 출처 데이터셋
- uspto-grants-1991_10
- 특허 번호
- US05061713
반응 노트
불러오는 중…