Ethanol → 4-Bromo-3-fluorobenzaldehyde
반응식
C([O:4][CH:5](OC(=O)C)[C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[C:8]([F:13])[CH:7]=1)(=O)C.C(O)C.O.S(=O)(=O)(O)O>CCOCC>[Br:12][C:9]1[CH:10]=[CH:11][C:6]([CH:5]=[O:4])=[CH:7][C:8]=1[F:13]참가 물질
6
실험 절차
A mixture of 4-bromo-3-fluorobenzylidene diacetate (15 g), ethanol (41 ml), water (41 ml) and concentrated sulphuric acid (4 ml) was heated to reflux for 3 hours. After cooling, ether (300 ml) was added and the aqueous layer separated. The organic phase was washed with saturated sodium carbonate and brine before drying over anhydrous magnesium sulphate and evaporation in vacuo. 4-Bromo-3-fluorobenzaldehyde was obtained as a solid (7.3 g).
후처리
- temperaturewas heated
- temperatureto reflux for 3 hours
- temperatureAfter cooling
- customthe aqueous layer separated
- washThe organic phase was washed with saturated sodium carbonate and brine
- dry with materialbefore drying over anhydrous magnesium sulphate and evaporation in vacuo
출처 및 근거
- ORD 기록
- ord-b2bf3b052c1e4a8cba5a34f25d501af9
- 출처 데이터셋
- uspto-grants-1991_10
- 특허 번호
- US05061726
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