Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-(4-Carbomethoxyphenyl)-4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-thiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methyl 4-carbamothioylbenzoate | HCID 11401319 | — |
| 반응물 | 2-Chloro-1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethanone | HCID 14726533 | — |
| 촉매 | Pyridine | HCID 1049 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 2-(4-Carbomethoxyphenyl)-4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-thiazole | HCID 14726542 | — |
반응 단계
3.2 g (16.5 moles) of 4-carbomethoxybe-nzothiamide and 4.2 g (16 millimoles) of 6-chloroacetyl-1,2,3,4-tetrahydro-1,1,,4,4-tetramethylnaphthalene (for preparation see Example 28) in 40 ml of isopropanol were refluxed for 1 hour with the addition of 2 drops of pyridine. The mixture was cooled, water was added and the crystals formed were filtered off under suction. Recrystallization from isopropanol and a trace of water gave 3.0 g of the title compound of melting point 138°-140° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05061705 |
| 출처 데이터셋 | uspto-grants-1991_10 |
| ORD ID | ord-5f1b4dfbe40a4283a968cffce353375e |
| 출처 메모 | uspto-grants-1991_10 |