Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → HCID 178468747, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Chloro-1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethanone | HCID 14726533 | — |
| 반응물 | 4-Amidinobenzoic acid ethyl ester hydrochloride | HCID 67790291 | — |
| 생성물 | HCID 178468747 | HCID 178468747 | — |
반응 단계
2.6 g (10 millimoles) of 6-chloroacetyl-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene (for preparation see Example 28), 2.1 g (10 millimoles) of 4-carbethoxybenzamidinium chloride and 5 g of potassium carbonate in 100 ml of dimethylformamide were refluxed for 1 hour. After cooling, the mixture was poured onto water and stirred for 10 minutes, and the precipitate formed was filtered off under suction. Purification by column chromatography (silica gel; 9 1 n-heptane/ethyl acetate) gave 0.3 g of the title compound of melting point 186°-188° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05061705 |
| 출처 데이터셋 | uspto-grants-1991_10 |
| ORD ID | ord-fd959b9ef2ca476eaf2cb88710c990f4 |
| 출처 메모 | uspto-grants-1991_10 |