3-Bromoaniline → N-(3-Bromophenyl)-6-nitroquinazolin-4-amine

HRID 346422

반응식

HRID 346422 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].Cl[C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=2)[N:13]=[CH:12][N:11]=1>C(O)(C)C>[Br:1][C:2]1[CH:3]=[C:4]([NH:5][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 115623-BromoanilineHCID 113562574-Chloro-6-nitroquinazoline

생성물 1

HCID 5328041N-(3-Bromophenyl)-6-nitroquinazolin-4-amine수율 95.4%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

3-Bromoaniline (1.72 grams, 10 mmol) was reacted with 4-chloro-6-nitroquinazoline (523 mg, 2.5 mmol), in iso-propylalcohol, as is described hereinabove, to give 4-[(3-bromophenyl)amino]-6-nitroquinazoline (823 mg, 95% yield), which was thereafter reacted (590 mg, 1.7 mmol) with hydrazine hydrate, according to the procedure described hereinabove, to give 4-[(3-bromophenyl)amino]-6-aminoquinazoline (332 mg, 62% yield).

출처 및 근거

ORD 기록
ord-6b124bb44fff450f8df54ca562c21af8
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07172749B2

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